VB Project unavailable once solution opened in Visual Studio 2010 - vb.net

I have a VB.NET project under Visual Studio 2010.
Each time I open the solution (which contains only one vb.net project), the solution explorer populates with the associated projects but appends "unavailable" next to the project name. Also, it appends "0 projects" next to the solution name.
Every time I right click and reload the project, it reloads quickly and then reverts back to unavailable.
Whats happens? I have tried to open VS 2010 in administrator mode and I get the same result.
However, If I open a command line prompt window as administrator and from that command line I launch VS 2010 in safe mode using below command:
devenv /safemode
... and then once VS 2010 opened I open the solution, it works.
So what's the problem?

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There is no editor available for XYZ.vb (my Form file name with full
path). Make sure the application for the file type (.vb) is installed.
I am able to open all other forms other then one in the same solution.
What and where can be the problem?

Tell the add-in to open Visual Studio and jump to debug mode on a certain line of code?

I have created a COM add-in for Excel.
I know that I can enter debug points into my code and then choose to "play" my code from Visual Studio. When a debug point is hit, execution stops and I enter debug mode.
But is it possible to create debug points that cause execution to stop and debug mode to start when I am not running my code via "play" in visual studio but just opening an Excel file as normal?
You can attach the debugger after you run Excel manually outside of Visual Studio. See Attach to Running Processes with the Visual Studio Debugger and How to: Attach to a Running Process for more information.

how to get items in solution explorer in visual basic 2010

When i Open Any Project in Visual Basic 2010 Express by Clicking on A File that has extension .sln, the project is opened but there is no items in solution explorer and i can't run the project
the following is the screenshot
thanks for help
Right-click the unloaded project and click "Reload".
If this is consistent then you are closing your solutions incorrectly. You do not want to use the Unload Project context menu item. Use File + Close Solution instead.

Visual Studio Tools for Office VSTO "customization assembly could not be found or could not be loaded"

I just installed Visual Studio 2012 Ultimate and I am trying to create a managed code extension project for Excel 2010 (32 bit Office Professional Plus). I have tried using the .NET 4.0 template contained in VS Ultimate for an Excel 2010 workbook. When I create the project everything looks fine until I run it.
Excel opens and I get the error message "The customization assembly could not be found or could not be loaded. You can still edit and save the document. Contact your administrator or the author of this document for further assistance." The details section is blank.
I have tried everything I could think of to figure this out and I have run out of ideas. I removed all addins from Excel except for the VSTO Design-Time Adaptor for Excel. I removed all personal macros. I set every directory I could think of to "trusted" in Excel and lowered the security settings for all options to "enabled (not recommended)". I completely uninstalled Visual Studio and re-installed. There are no errors or warnings showing up in Visual Studio. I also checked to make sure ".NET Programmability Support" was installed for my copy of Microsoft Excel.
I would link my code but I haven't written anything. I can't even get the default template to load when I run the project. A few others at work have the same setup as me and VSTO runs fine for them using the same steps. I even had someone send me a working project but it gives me the same message when I try to run it.
Is there anything else I can check to see where the problem is occurring? I tried setting break points in the project but it is failing before it gets to any of them.
Thanks so much for your help.
I've run into the same problem with Visual Studio 2010.
I isolated the problem to an SSRS reporting link we were trying to run from the add-in. I removed all the reporting stuff (service reference, sub-dirs, etc.) - the add-in runs fine.
We just ran into this and discovered that a method had a system exception that was not handled. It was hard to track down but once the culprit method had an exception handler the customization finished loading properly.

Unable to start debugging - Visual Studio 2012

"Unable to start debugging 'C:\Windows\System32\WWAHost.exe'. The Microsoft Visual Studio Remote Debugging Monitor (MSVSMON.EXE) does not appear to be running on the remote computer. This may be because a firewall is preventing communication to the remote computer. Please see Help for assistance on configuring remote debugging."
Searched for similar posts, but didn't found one. If duplicate just inform.
I am not trying to connect to any remote machine. Just testing on my local machine.
Is there any way to solve this issue. (I'm using Windows 8 Enterprise 64-bit, just a javascript project)
Problem solved. Installed Remote tools update from here and working fine. Thanks for responding. Closing the topic.
I had the same problem. I fixed it by changing properties/compile/target platform to x86 instead of Any CPU. It solved the problem in my case. Hope it helps.
This happened to me just now when I had a website set up in IIS for mydomain.com, and set my project's start up url (Local IIS) to mydomain.com, and then launched the project before remembering to add a record in the host files for the domain:
127.0.0.1 mydomain.com
This got me for a good hour before I remembered I never set the record. Adding the record fixed it right away.
Windows 7 x64, VS 2012
In my case, the Remote Debugging Monitor component was installed and the app was clearly configured to debug locally in settings. This was a WinForms app upgraded from VS 2008, .NET 3.5.
Turns out it was the Windows Firewall. By directly running:
C:\Program Files (x86)\Microsoft Visual Studio 11.0\Common7\IDE\Remote Debugger\x64\msvsmon.exe
A firewall dialog appeared where I could allow msvsmon.exe to run. After a VS 2012 re-start, debugging (locally) was fine!
Ensure you have Local Machine selected in this drop-down menu:
Windows 7 x64, VS 2012, VB.NET
I fixed it like this:-
Create a shortcut on your desktop to "C:\Program Files (x86)\Microsoft Visual Studio 11.0\Common7\IDE\Remote Debugger\x64\msvsmon.exe".
Right-click shortcut and select "Properties" from the dropdown menu. Select the "Compatibity" tab, tick "Run this program as administrator" and click OK
Create a shortcut on your desktop to "C:\Program Files (x86)\Microsoft Visual Studio 11.0\Common7\IDE\devenv.exe".
Right-click shortcut and select "Properties" from the dropdown menu. Select the "Compatibity" tab, tick "Run this program as administrator" and click OK.
To start VS2012:-
Double-click the msvsmon shortcut icon (that you created above, to launch msvsmon). Wait for the "Visual Studio Remote Debugging Monitor (Administrator)" window to display before continuing ...
Double-click the "Visual Studio 2012 Professional" shortcut icon (that you created above, to launch VS2012)
In VS2012, ensure standard toolbar is visible.
In VS2012, ensure "Solution Platforms" dropdown (on standard toolbar) is visible and set to "x86".
and debug now works (for me anyway) ...
However after 15 minutes or so, debug may stop working and you may get the msvsmon error again. If that happens, simply close VS2012 and msvsmon and then start again (from "To start VS2012:-" above) ...
Myself and several other developers have been trying to look for a solution for this problem for about 3/4 hours as Visual Studio crashed then this error would occur (twice in 2 days). I then suddenly (after a lot of debugging and trying other suggestions and headbanging) I somehow realised that the file which was highlighted had changed and when I was trying to debug was not the MVC app project, once I changed it to my project's one it then worked.
Hope this helps and saves people from hours of pain!
I also got this error, I usually run sites under a named user (which is also a database user) and forgot to set the Application Pool. (parliament's answer also helped me)
For me this worked in VS2013:
Save your work, close Visual Studio then reopen your project
I encountered this error as well.
The cause of mine was that I had accidentally emptied out the following property
Properties->Debugging->WorkingDirectory
Changing it to:
inherit from parent or project defaults
Solved the issue.
If you are using Microsoft's Azure, try attaching manually the debugger:
I have outlined the steps in the following answer:
https://stackoverflow.com/a/35738995/1057052